The PRKAR2B (5G1) Monoclonal Antibody from Bioss Inc. is a Rabbit Monoclonal antibody to PRKAR2B. This antibody recognizes Human, Mouse, and Rat antigen. The PRKAR2B (5G1) Monoclonal Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
PRKAR2B is a regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol